·
COMMENTARY
·

A novel strategy for treating acute liver failure: encapsulated proliferating human hepatocyte organoids

Xiangying Meng2,3 Aihui Liu1,3 Oulayvanh Phangthavong1,3 Yi Sun1,2,3,4
Show Less
1 Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, Hubei Province, China
2 Hunan Guangxiu Hospital, Hunan Normal University, Changsha, Hubei Province, China
3 National Engineering and Research Center of Human Stem Cells, Changsha, Hubei Province, China
4 Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, Hubei Province, China
Submitted: 22 October 2024 | Revised: 29 October 2024 | Accepted: 30 October 2024 | Published: 28 December 2024
Copyright © 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution–NonCommercial–ShareAlike 4.0 License.
References

Below is the content of the Citations in the paper which has been de-formatted, however, the content stays consistent with the original.

1. McSteen, B. W.; Ying, X. H.; Lucero, C.; Jesudian, A. B. Viral etiologies of acute liver failure. World J Virol. 2024, 13, 97973.
2. Devarbhavi, H.; Asrani, S. K.; Arab, J. P.; Nartey, Y. A.; Pose, E.; Kamath, P. S. Global burden of liver disease: 2023 update. J Hepatol. 2023, 79, 516 - 537.
3. Tadokoro, T.; Murata, S.; Kato, M.; Ueno, Y.; Tsuchida, T.; Okumura, A.; Kuse, Y.; Konno, T.; Uchida, Y.; Yamakawa, Y.; Zushi, M.; Yajima, M.; Kobayashi, T.; Hasegawa, S.; Kawakatsu - Hatada, Y.; Hayashi, Y.; Osakabe, S.; Maeda, T.; Kimura, K.; Mori, A.; Tanaka, M.; Kamishibahara, Y.; Matsuo, M.; Nie, Y. Z.; Okamoto, S.; Oba, T.; Tanimizu, N.; Taniguchi, H. Human iPSC - liver organoid transplantation reduces fibrosis through immunomodulation. Sci TranslMed. 2024, 16, eadg0338.
4. Liu, Q.; Wang, S.; Fu, J.; Chen, Y.; Xu, J.; Wei, W.; Song, H.; Zhao, X.; Wang, H. Liver regeneration after injury: Mechanisms, cellular interactions and therapeutic innovations. Clin Transl Med. 2024, 14, e1812.
5. Zhang, K.; Zhang, L.; Liu, W.; Ma, X.; Cen, J.; Sun, Z.; Wang, C.; Feng, S.; Zhang, Z.; Yue, L.; Sun, L.; Zhu, Z.; Chen, X.; Feng, A.; Wu, J.; Jiang, Z.; Li, P.; Cheng, X.; Gao, D.; Peng, L.; Hui, L. In vitro expansion of primary human hepatocytes with efficient liver repopulation capacity. Cell Stem Cell. 2018, 23, 806 - 819.e4.
6. Fu, G. B.; Huang, W. J.; Zeng, M.; Zhou, X.; Wu, H. P.; Liu, C. C.; Wu, H.; Weng, J.; Zhang, H. D.; Cai, Y. C.; Ashton, C.; Ding, M.; Tang, D.; Zhang, B. H.; Gao, Y.; Yu, W. F.; Zhai, B.; He, Z. Y.; Wang, H. Y.; Yan, H. X. Expansion and differentiation of human hepatocyte - derived liver progenitor - like cells and their use for the study of hepatotropic pathogens. Cell Res. 2019, 29, 8 - 22.
7. Yuan, X.; Wu, J.; Sun, Z.; Cen, J.; Shu, Y.; Wang, C.; Li, H.; Lin, D.; Zhang, K.; Wu, B.; Dhawan, A.; Zhang, L.; Hui, L. Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure. Cell Stem Cell. 2024, 31, 484 - 498.e5.
8. Lee, K. Y.; Mooney, D. J. Alginate: properties and biomedical applications. Prog Polym Sci. 2012, 37, 106 - 126.
9. Lopez - Mendez, T. B.; Santos - Vizcaino, E.; Pedraz, J. L.; Hernandez, R. M.; Orive, G. Cell microencapsulation technologies for sustained drug delivery: Clinical trials and companies. Drug Discov Today. 2021, 26, 852 - 861.
10. Dhawan, A.; Chaijitraruch, N.; Fitzpatrick, E.; Bansal, S.; Filippi, C.; Lehec, S. C.; Heaton, N. D.; Kane, P.; Verma, A.; Hughes, R. D.; Mitry, R. R. Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children. J Hepatol. 2020, 72, 877 - 884.
11. Fitzpatrick, E.; Filippi, C.; Jagadisan, B.; Shivapatham, D.; Anand, H.; Lyne, M.; Stroud, K. D.; Newton, R.; DeLord, M.; Douiri, A.; Dhawan, A. Intraperitoneal transplant of Hepatocytes co - Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute liver failure in pediatric patients (HELP) - an open - label, single - arm Simon’s two stage phase 1 study protocol. PLoS One. 2023, 18, e0288185.
12. Kang, A.; Park, J.; Ju, J.; Jeong, G. S.; Lee, S. H. Cell encapsulation via microtechnologies. Biomaterials. 2014, 35, 2651 - 2663.

Conflict of interest
The authors declare they have no competing interests.
Share
Back to top