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COMMENTARY
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Biomimetic rhythm programming and intelligent delivery: The BRIGHT transdermal patch revolutionizes chronotherapy for growth hormone treatment
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College of Life Science and Technology, Beijing University of Chemical Technology, Beijing,
China
BMT, 00015 https://doi.org/10.12336/bmt.25.00015
Submitted: 9 April 2025 | Revised: 6 May 2025 | Accepted: 9 May 2025 | Published: 5 June 2025
Copyright © 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution–NonCommercial–ShareAlike 4.0 License.
Funding
This work was supported by the Beijing Natural Science Foundation- Changping Innovation Joint Fund (L234016).
Conflict of interest
The authors declare no conflicts of interest.
References
Below is the content of the Citations in the paper which has been de-formatted, however, the content stays consistent with the original.
[1]
- Maury E, Navez B, Brichard SM. Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation. Nat Commun. 2021;12:2388. doi: 10.1038/s41467-021-22571-9
- Chaput JP, McHill AW, Cox RC, et al. The role of insufficient sleep and circadian misalignment in obesity. Nat Rev Endocrinol. 2023;19:82-97. doi: 10.1038/s41574-022-00747-7
- Wei Y, Wang Y, Kang A, et al. A novel sustained-release formulation of recombinant human growth hormone and its pharmacokinetic, pharmacodynamic and safety profiles. Mol Pharm. 2012;9:2039-2048. doi: 10.1021/mp300126t
- Cotterill AM, Holly JM, Snodgrass GA, Savage MO. Regulation of growth hormone secretion in patients with growth hormone insensitivity. Acta Paediatr Scand Suppl. 1991;377:92-95. doi: 10.1111/apa.1991.80.s377.92
- Li B, Wang X, Yang C, et al. Human growth hormone proteoform pattern changes in pituitary adenomas: Potential biomarkers for 3P medical approaches. EPMA J. 2021;12:67-89. doi: 10.1007/s13167-021-00232-7
- Liao S, Vickers MH, Evans A, Stanley JL, Baker PN, Perry JK. Comparison of pulsatile vs. Continuous administration of human placental growth hormone in female C57BL/6J mice. Endocrine. 2016;54:169-181. doi: 10.1007/s12020-016-1060-0
- Hindmarsh PC, Matthews DR, Brook CG. Growth hormone secretion in children determined by time series analysis. Clin Endocrinol (Oxf). 1988;29:35-44. doi: 10.1111/j.1365-2265.1988.tb00247.x
- Su PH, Malik S, Jheeta A, et al. Investigating the impact of the TUITEK® patient support programme, designed to support caregivers of children prescribed recombinant human growth hormone treatment in taiwan. Front Endocrinol (Lausanne). 2022;13:897956. doi: 10.3389/fendo.2022.897956
- Han J, Wu Z, Zhan S, et al. Biorhythm-mimicking growth hormone patch. Nat Mater. 2025. doi: 10.1038/s41563-025-02188-9
- Jang D, Tang J, Schwendeman SP, Prausnitz MR. Effect of surface interactions on microsphere loading in dissolving microneedle patches. ACS Appl Mater Interfaces. 2022;14:29577-29587. doi: 10.1021/acsami.2c05795
- Li S, Xia D, Prausnitz MR. Efficient drug delivery into skin using a biphasic dissolvable microneedle patch with water-insoluble backing. Adv Funct Mater. 2021;31:2103359. doi: 10.1002/adfm.202103359
- Fan L, Zhang X, Nie M, et al. Photothermal responsive microspheres-triggered separable microneedles for versatile drug delivery. Advan Functional Mater. 2022;32:2110746. doi: 10.1002/adfm.202110746
- Meng E, Hoang T. MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications. Adv Drug Deliv Rev. 2012;64:1628-1638. doi: 10.1016/j.addr.2012.08.006
- Verma RK, Arora S, Garg S. Osmotic pumps in drug delivery. Crit Rev Ther Drug Carrier Syst. 2004;21:477-520. doi: 10.1615/critrevtherdrugcarriersyst.v21.i6.20
- Gungor-Ozkerim PS, Balkan T, Kose GT, Sarac AS, Kok FN. Incorporation of growth factor loaded microspheres into polymeric electrospun nanofibers for tissue engineering applications. J Biomed Mater Res A. 2014;102:1897-1908. doi: 10.1002/jbm.a.34857
- Alten R. Chronotherapy with modified-release prednisone in patients with rheumatoid arthritis. Expert Rev Clin Immunol. 2012;8:123-133. doi: 10.1586/eci.11.95
- Yang R, Yang Z, Chi J, Zhu Y. Insulin delivery devices in diabetes management: Applications and advancements. Intell Pharm. 2025. doi: 10.1016/j.ipha.2025.02.002
- Lévi F, Okyar A, Dulong S, Innominato PF, Clairambault J. Circadian timing in cancer treatments. Annu Rev Pharmacol Toxicol. 2010;50:377-421. doi: 10.1146/annurev.pharmtox.48.113006.094626
- Van Cauter E, Kerkhofs M, Caufriez A, Van Onderbergen A, Thorner MO, Copinschi G. A quantitative estimation of growth hormone secretion in normal man: Reproducibility and relation to sleep and time of day. J Clin Endocrinol Metab. 1992;74:1441-1450. doi: 10.1210/jcem.74.6.1592892
- Van Cauter E, Plat L. Physiology of growth hormone secretion during sleep. J Pediatr. 1996;128:S32-S37. doi: 10.1016/s0022-3476(96)70008-2
- Arya J, Henry S, Kalluri H, McAllister DV, Pewin WP, Prausnitz MR. Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects. Biomaterials. 2017;128:1-7. doi: 10.1016/j.biomaterials.2017.02.040
- Forster AH, Witham K, Depelsenaire ACI, et al. Safety, tolerability, and immunogenicity of influenza vaccination with a high-density microarray patch: Results from a randomized, controlled phase I clinical trial. PLoS Med. 2020;17:e1003024. doi: 10.1371/journal.pmed.1003024
- Sabbagh F, Kim BS. Microneedles for transdermal drug delivery using clay-based composites. Expert Opin Drug Deliv. 2022;19:1099-1113. doi: 10.1080/17425247.2022.2119220
- Al-Japairai KA, Mahmood S, Hamed Almurisi S, et al. Current trends in polymer microneedle for transdermal drug delivery. Int J Pharm. 2020;587:119673. doi: 10.1016/j.ijpharm.2020.119673
- Veldhuis JD, Roemmich JN, Richmond EJ, Bowers CY. Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition. Endocr Rev. 2006;27:101-140. doi: 10.1210/er.2005-0006
- Thakor AS, Gambhir SS. Nanooncology: The future of cancer diagnosis and therapy. CA Cancer J Clin. 2013;63:395-418. doi: 10.3322/caac.21199
- Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev. 1997;28:5-24. doi: 10.1016/s0169-409x(97)00048-3