News and Announcements
COMMENTARY
Limitations of the porcine model in post-total laryngectomy research
Show Less
1
Department of Surgery, Oncopole Claudius Regaud, University Cancer Institute of Toulouse – Oncopole, University of Toulouse, Toulouse, Occitanie,
France
2
Département Hospitalo- Universitaire de Recherche et d’Enseignement (DHURE), Lille University Hospital, Faculty of Medicine, Lille University, Lille, Hauts-de-France,
France
3
Department of Surgery, Toulouse University Hospital, University Cancer Institute of Toulouse – Oncopole, University of Toulouse, Toulouse, Occitanie,
France
Submitted: 15 November 2025 | Revised: 26 March 2026 | Accepted: 31 March 2026 | Published: 12 May 2026
© 2026 by the Author(s). Licensee Biomaterials Translational, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 (CC BY-NC-SA 4.0) (https://creativecommons.org/licenses/by-nc-sa/4.0/deed.en)
Funding
The animal experiments referred to in this article were funded by the French National Research Agency (grant number ANR-20-CE19-0022).
Conflict of interest
The authors declare no conflicts of interest.
References
- Murison PJ, Jones A, Mitchard L, Burt R, Birchall MA. Development of perioperative care for pigs undergoing laryngeal transplantation: A case series. Lab Anim. 2009;43(4):338-343. doi: 10.1258/la.2009.008101
- Birchall MA, Kingham PJ, Murison PJ, et al. Laryngeal transplantation in minipigs: Vascular, myologic and functional outcomes. Eur Arch Otorhinolaryngol. 2011;268(3):405-414. doi: 10.1007/s00405-010-1355-3
- Knight MJ, McDonald SE, Birchall MA. Intrinsic muscles and distribution of the recurrent laryngeal nerve in the pig larynx. Eur Arch Otorhinolaryngol. 2005;262(4):281-285. doi: 10.1007/s00405-004-0803-3
- Alcalá Rueda I, Villacampa Aubá JM, Encinas Vicente A, et al. A live porcine model for surgical training in tracheostomy, neck dissection, and total laryngectomy. Eur Arch Otorhinolaryngol. 2021; 278(8):3081-3090. doi: 10.1007/s00405-021-06613-y
- Payen C, Carsuzaa F, Kucharczak F, et al. Swine model for total laryngectomy training: Assessment of the face, content, and construct validity. Eur Arch Otorhinolaryngol. 2025;282(12):6635-6643. doi: 10.1007/s00405-025-09408-7
- Chabrillac E, Tourrette A, Habib M, et al. Application of biomaterials for the prevention of pharyngeal fistulae: A systematic review. Head Neck. 2025;47(7):2048-2057. doi: 10.1002/hed.28175
- Chabrillac E, Baudel L, Vergez S, et al. Videofluoroscopic swallowing study to detect pharyngeal leak after total (pharyngo-) laryngectomy: Retrospective assessment of a single-institution protocol. Head Neck. 2024;46(4):740-748. doi: 10.1002/hed.27617
- Birchall MA, Bailey M, Barker EV, Rothkötter HJ, Otto K, Macchiarini P. Model for experimental revascularized laryngeal allotransplantation. Br J Surg. 2002;89(11):1470-1475. doi: 10.1046/j.1365-2168.2002.02234.x
- Azad MK, Mansy HA, Gamage PT. Geometric features of pig airways using computed tomography. Physiol Rep. 2016;4(20):e12995. doi: 10.14814/phy2.12995
- Han MN, Kim JH, Choi SH. Evaluation of biomechanical properties and morphometric structures of the trachea in pigs and rabbits. In Vivo. 2022;36(4):1718-1725. doi: 10.21873/invivo.12884
- Barone R. Anatomie Comparee Des Mammiferes Domestiques. Splanchnologie II. Appareil Urogenital, Foetus Et Ses Annexes, Peritoine Et Topographie Abdominale [Comparative Anatomy of Domestic Mammals. Splanchnology II. Urogenital System, Fetus and its Annexes, Peritoneum and Abdominal Topography]. Vol. 4. Mumbai: Vigot; 2001.
- Ten Hallers EJO, Marres HAM, Rakhorst G, et al. The Saanen goat as an animal model for post-laryngectomy research: Practical implications. Lab Anim. 2007;41(2):270-284. doi: 10.1258/002367707780378159
- Matz BM, Henderson RA, Lindley SS, Smith AN. Total laryngectomy and permanent tracheostomy in six dogs. Vet Comp Oncol. 2021; 19(4):678-684. doi: 10.1111/vco.12681
- Vincenti S, Betting A, Durand A, Campos M, Scanziani E, Martin SS. Total laryngectomy in a cat with a laryngeal peripheral nerve sheath tumor. Vet Surg. 2021;50(7):1533-1541. doi: 10.1111/vsu.13646
- Stierschneider M, Franz S, Baumgartner W. Endoscopic examination of the upper respiratory tract and oesophagus in small ruminants: Technique and normal appearance. Vet J. 2007;173(1):101-108. doi: 10.1016/j.tvjl.2005.09.002
