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Integrating nanomedicine and immunotherapy: Bacterial membrane–derived vesicle-encapsulated prodrug assemblies for chronic infections
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1
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan,
China
2
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan,
China
3
Department of Biomedical Polymers and Artificial Organs, State Key Laboratory of Polymer Materials Engineering,College of Polymer Science and Engineering, Sichuan University, Chengdu, Sichuan,
China
Submitted: 20 August 2025 | Revised: 6 November 2025 | Accepted: 18 November 2025 | Published: 17 December 2025
© 2025 by the Author(s). Licensee Biomaterials Translational, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 (CC BY-NC-SA 4.0) (https://creativecommons.org/licenses/by-nc-sa/4.0/deed.en)
Funding
None.
Conflict of interest
The authors declare no conflicts of interest.
References
- Young D, Hussell T, Dougan G. Chronic bacterial infections: Living with unwanted guests. Nat Immunol. 2002;3(11):1026-1032. doi: 10.1038/ni1102-1026
- Hou X, Zhang X, Zhao W, et al. Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis. Nat Nanotechnol. 2020;15(1):41-46. doi: 10.1038/s41565-019-0600-1
- Xie Y, Liu H, Teng Z, Ma J, Liu G. Nanomaterial-enabled anti-biofilm strategies: New opportunities for treatment of bacterial infections. Nanoscale. 2025;17(10):5605-5628. doi: 10.1039/D4NR04774E
- Uberoi A, McCready-Vangi A, Grice EA. The wound microbiota: Microbial mechanisms of impaired wound healing and infection. Nat Rev Microbiol. 2024;22(8):507-521. doi: 10.1038/s41579-024-01035-z
- Makabenta JMV, Nabawy A, Li CH, Schmidt-Malan S, Patel R, Rotello VM. Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections. Nat Rev Microbiol. 2021;19(1):23-36. doi: 10.1038/s41579-020-0420-1
- Arciola CR, Campoccia D, Montanaro L. Implant infections: Adhesion, biofilm formation and immune evasion. Nat Rev Microbiol. 2018;16(7):397-409. doi: 10.1038/s41579-018-0019-y
- Heim CE, Bosch ME, Yamada KJ, et al. Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection. Nat Microbiol. 2020;5(10):1271-1284. doi: 10.1038/s41564-020-0756-3
- Tyers M, Wright GD. Drug combinations: A strategy to extend the life of antibiotics in the 21st century. Nat Rev Microbiol. 2019;17(3):141-155. doi: 10.1038/s41579-018-0141-x
- Nürnberger T, Kemmerling B. Pathogen-associated molecular patterns (PAMP) and PAMP-triggered immunity. In: Annual Plant Reviews Online. New Jersey: Wiley; 2018. p. 16-47.
- Han R, Wang W, Zhou Y, et al. Extracellular vesicles in antimicrobial therapy: Advances, challenges and perspectives. Chem Eng J. 2025;520:166067. doi: 10.1016/j.cej.2025.166067
- Li Y, He W, Piao Y, et al. Bacterial membrane nanovesicles encapsulating prodrug assemblies combine chemical and immunological therapies for chronic bacterial infection. Nat Commun. 2025;16(1):5246. doi: 10.1038/s41467-025-60570-2
- Pelaz B, Alexiou C, Alvarez-Puebla RA, et al. Diverse applications of nanomedicine. ACS Nano. 2017;11(3):2313-2381. doi: 10.1021/acsnano.6b06040
- Fang RH, Kroll AV, Gao W, Zhang L. Cell membrane coating nanotechnology. Adv Mater. 2018;30(23):e1706759. doi: 10.1002/adma.201706759
- Liu H. Repair Mechanisms in Abdominal Tissue: Promotion of Fascial Healing and Prevention of Intra-Abdominal Adhesions. [Doctoral Thesis]. Maastricht University; 2021.
- Madej M, Kurowska N, Strzalka-Mrozik B. Polymeric nanoparticles-tools in a drug delivery system in selected cancer therapies. Appl Sci. 2022;12(19):9479. doi: 10.3390/app12199479
- Groner J, Goepferich A, Breunig M. Atherosclerosis: Conventional intake of cardiovascular drugs versus delivery using nanotechnology - a new chance for causative therapy? J Control Release. 2021;333:536-559. doi: 10.1016/j.jconrel.2021.03.034
- Li M, Zhou H, Yang C, et al. Bacterial outer membrane vesicles as a platform for biomedical applications: An update. J Control Release. 2020;323:253-268. doi: 10.1016/j.jconrel.2020.04.031
- Xu X, Xu L, Wen C, Zhang Y, Xia J, Liang Y. Engineering bacterial membrane vesicles: A new paradigm in biomedical innovation. Coord Chem Rev. 2025;543:216895. doi: 10.1016/j.ccr.2025.216895
- Castillo-Romero KF, Santacruz A, González-Valdez J. Production and purification of bacterial membrane vesicles for biotechnology applications: Challenges and opportunities. Electrophoresis. 2023; 44(1-2):107-124. doi: 10.1002/elps.202200133
- Zahid A, Ismail H, Wilson JC, Grice ID. Bioengineering outer-membrane vesicles for vaccine development: Strategies, advances, and perspectives. Vaccines (Basel). 2025;13(7):767. doi: 10.3390/vaccines13070767
- Bates SM, Evans KV, Delsing L, Wong R, Cornish G, Bahjat M. Immune safety challenges facing the preclinical assessment and clinical progression of cell therapies. Drug Discov Today. 2024;29(12):104239. doi: 10.1016/j.drudis.2024.104239
