Publishing Organization

The journal publishing organization, Chinese Medical Multimedia Press, was established in 1987 and is supervised by the National Health Commission of the People's Republic of China and sponsored by the Chinese Medical Association. It has become an all-media professional publishing unit integrating electronic audiovisual, electronic journals, books, and Internet publishing qualifications and has published 43 electronic journals, forming the largest medical electronic journal cluster in China with great professional influence in the medical field.

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Host Organization

The journal host organization, the Chinese Medical Association (CMA), is a non-profit national academic organization in China. Established in 1915, the CMA now has 89 specialty societies and about 700,000 members in China. CMA edits and publishes 191 medical and popular science journals including print and electronic, books and over 3,000 products including audio-visual and digital. It is an important social force in the development of medical science and technology and a linkage between the government and medical professionals.

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Organizing Organization

The journal organizing organization, Shanghai University, was founded in 1922. It is ranked as the 22nd best university in China and is placed in the top 300 universities around the world. It is also supported by the national Double First-Class Initiative and holds profound academic traditions and outstanding research facilities, with 11 disciplines entering the top 1% of the ESI global rankings while material science, chemistry and engineering have already reached the top 1‰.

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Journal Data

154

Articles

47803

Article Views

712

Article Downloads

43 days

Submission to Final Descision

25 days

Acceptance to Publication

Indexing & Archiving

The Biomaterials Translational is indexed and archived in the following databases

Articles

Ångstrom-scale silver particle-infused hydrogels eliminate orthopedic implant infections and support fracture healing

Wei Du Jiang-Shan Gong Xia Chen Yang Wu Yu Yang Sheng Zhu Yu Zhang Bei Chen Yi-Wei Liu Ze-Hui He Zhe Guan Yan Zhang* Zhen-Xing Wang* Hui Xie*

2025, 6(1): 85–102. https://doi.org/10.12336/biomatertransl.2025.01.007

Orthopedic implant-associated infections pose a significant clinical challenge, often requiring surgical intervention along with systemic antibiotic treatments. To address this issue, we developed a novel approach using Ångstrom-scale silver particles (AgÅPs) with broad-spectrum antibacterial properties. Specifically, we formulated a polyethylene glycol hydrogel infused with AgÅPs (Gel-AgÅPs) designed for treating fracture fixation infections. This novel hydrogel formulation is injectable, ensuring precise adherence to both the exposed tissue and fracture surfaces, thereby allowing the direct targeted action of AgÅPs at the infection site. The Gel-AgÅPs significantly reduced the infection caused by Escherichia coli (a model pathogen of orthopedic implant infection) in a murine femoral fracture model. Moreover, the Gel-AgÅPs-treated infected fractures healed completely within 6 weeks, exhibiting bone formation and mechanical strength comparable to those of uninfected fractures. Further analysis revealed a significant downregulation of local inflammatory response as evidenced by a lower expression of inflammatory markers in Gel-AgÅPs-treated fractures compared to untreated infected controls. Furthermore, Gel-AgÅPs exhibited a unique ability to inhibit osteoclast differentiation, a critical factor in infection-induced bone degradation, without impacting osteoblast activity. In conclusion, Gel-AgÅPs exerted a dual therapeutic effect by eradicating bacterial infection and mitigating inflammation-induced osteoclast activity, thereby expediting infected fracture healing. This innovative approach is a promising therapeutic alternative to conventional antibiotic treatments, potentially transforming the treatment landscape for orthopedic implant-associated infections.

Supplementary Material | References | Related Articles

Living hybrid material based on probiotic with photothermal properties inhibits PD-L1 expression after tumouricidal photothermal therapy

Ning Jiang Mingyan Jiang Jianshu Chen Ali Mohsin Yuqing Mu Xiaoping Yi Yingping Zhuang Jiangchao Qian Jiaofang Huang*

2025, 6(1): 73–84. https://doi.org/10.12336/biomatertransl.2025.01.006

Photothermal therapy is a safe and effective tumour treatment strategy due to its excellent spatiotemporal controllability. However, interferon gamma in the tumour microenvironment is upregulated after photothermal therapy, which enhances the expression of programmed cell death ligand 1 (PD-L1) in tumour cells. This further promotes immunosuppression and tumour metastasis, resulting in a poor prognosis in cancer therapy. Traditional nanodrugs often face challenges in penetrating the dense extracellular matrix of solid tumours, whereas certain probiotics possess the ability to specifically colonise the core regions of tumours. In this research, we used Escherichia coli Nissle 1917 (ECN) as a chassis cell and self-assembly polydopamine (PDA) on the ECN surface. The black PDA@ECN (notes as PE) actively colonises at the tumour site and produces a photothermal effect under 808 nm laser irradiation to kill tumour cells. To overcome the high expression of PD-L1 induced after photothermal therapy, metformin (MET) was also encapsulated in PE to form PDA@MET@ECN (notes as PME). In vivo experiments demonstrated that PME effectively inhibited the PD-L1 expression and growth of CT26 tumour cells. Overall, PME reverses the immunosuppressive tumour microenvironment and enhances the effect of photothermal/immune therapy in tumour treatment.

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Special Issues

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Catalytic Biomaterials for Disease Theranostics

Guest Editors: Yu Chen, Liang Chen
Submission Deadline: 28 February 2025

Hydrogel Microspheres and Regenerative Medicine in Biomaterials Translational

Guest Editors: Wenguo Cui, Yiting Lei
Submission Deadline: 25 January 2024
Announcement
02 April 2025
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